Literature Reference – Andrographis paniculata Extract & Bioimmune

(1). In vitro anti-viral study against SARS CoV-2 virus, established that Bio-ImmuneTM inhibited the replication of SARS CoV 2 virus with >99% inhibition of SARS CoV-2 virus replication.


Ref. Source:
S.C. Singh, D.K. Khatri, K. Singh, V.K. Kanchupalli, J. Madan, S.B. Singh, S. Singh. Molecular encapsulation of andrographolide in 2-hydroxypropyl-β-cyclodextrin cavity: Synthesis, characterization, pharmacokinetic and in vitro antiviral activity analysis against SARS-CoV-2, Heliyon 2021; 7(8):e07741.

(2). The compound Andrographolide from Andrographis paniculata has been found to be a potential inhibitor of the main protease of SARS-COV-2 (Mpro) through in silico studies such as molecular docking, target analysis, toxicity prediction and ADME prediction.


Ref. Source:
S.K. Enmozhi, K. Raja, I. Sebastine, J. Joseph, Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach, J. Biomol. Struct. Dyn. (2020).

(3). Postinfection treatment of A. paniculata and andrographolide in SARS-CoV-2-infected Calu-3 cells significantly inhibited the production of infectious virions with an IC50 of 0.036 μg/mL and 0.034 μM, respectively, as determined by the plaque assay.


Ref. Source:
Anti-SARS-CoV-2 Activity of Andrographis paniculata Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives. J Nat Prod. 2021 Apr 23; 84(4): 1261–1270.)

(4). A placebo-controlled, double-blind clinical trial assessed the efficacy of a Andrographis paniculata standardized extract of the aerial parts (containing 4% andrographolides) for treatment of the common cold. A significant reduction (P < 0.0001) in clinical symptoms of common cold such as sore throat, tiredness, muscular ache and malaise was observed on day 4 in the group receiving 1200 mg aerial part extract containing 4% andrographolides.


Ref. Source:
Hancke J et al. A double-blind study with a new monodrugkanjang: decrease of symptoms and improvement in the recovery from common colds. Phytotherapy Research, 1995, 9:559–562.)

(5). A randomized, placebo-controlled, double-blind pilot trial conducted to evaluate the efficacy of a Andrographis paniculata standardized extract of the aerial parts (containing 4% andrographolides) on the initial symptoms of the common cold and uncomplicated sinusitis. A. paniculata (containing 4% andrographolides) has been found beneficial for treatment of initial symptoms of the common cold and uncomplicated sinusitis. Also 55% of the treated patients thought that the course of illness was much easier than normal, as compared with 19% of the placebo group.


Ref. Source:
Melchior J et al. Controlled clinical study of standardized Andrographis paniculata extract in common cold - a pilot trial. Phytomedicine, 1997, 3:315–318.)

(6). A clinical trial compared the efficacy of HerbaAndrographidis, co-trimoxazole (sulfamethoxazole + trimethoprim) and norfloxacin in the prevention of urinary tract infections after extracorporeal shock wave lithotripsy. After 1 month of treatment, urinalysis results of 100 patients demonstrated that pyuria, haematuria and proteinuria were reduced in all treatment groups , and there was no significant difference between the three treatments.


Ref. Source:
Muangman V et al. The usage of Andrographis paniculata following extracorporeal shock wave lithotripsy (ESWL). Journal of the Medical Association of Thailand, 1995, 78:310–313.)

(7). A randomized, double-blind clinical study of patients compared the efficacy of the powdered aerial parts of Andrographis paniculata with tetracycline in the treatment of acute diarrhoea and bacillary dysentery. Compared with tetracycline, the aerial parts of A. paniculata decreased the diarrhoea (both the frequency and amount of discharge).


Ref. Source:
Thanagkul B, Chaichantipayut C. Double-blind study of Andrographis paniculataNees and tetracycline in acute diarrhoea and bacillary dysentery. Ramathibodi Medical Journal, 1985, 8:57–61.)

(8). A clinical study on Andrographis paniculataNees in the decoction form to the patients of infective hepatitis has been done. Patients noticed improvement in appetite on the fifth day of the treatment and gradually reached the normal state of appetite within 24 days. The yellow colour of urine gradually became normal within 3 weeks of treatment in all the patients. Similarly the yellow colour of conjunctiva was gradually diminished and completely disappeared within 24 days of treatment. Fever, which was noted in 19 subjects (95%) subsided on the 7th day(average) of treatment in all the subjects. Tender hepatic enlargement was observed in 18 subjects (90%) and relieved completely within average (24 days) duration of treatment in 16 subjects.


Ref. Source:
https://www.researchgate.net/publication/224898221_Clinical_studies_on_kalmegh_andrographis_paniculata_nees_in_infective_hepatitis)